Table 1.
Example dissociation half-lifes of several G protein-coupled receptor ligands
| Receptor | Ligand | Dissociation half-life (t1/2) | References |
|---|---|---|---|
| M3 muscarinic receptor | Tiotropium | 7.7 h | Dowling and Charlton, 2006 |
| Ipratropium | 0.16 h | ||
| CCR5 chemokine receptor | Maraviroc | 136 h | Watson et al., 2005 |
| 873140 | >136 h | ||
| µ opioid receptor | Alvimopan | 30–44 min | Cassel et al., 2005 |
| N-methylnaloxone | 0.46 min | ||
| Histamine H1 receptor | Desloratidine | >8.7 h | Anthes et al., 2002 |
| GSK1004723 | 5.8 h | Slack et al., 2009 | |
| Angiotensin type 1 receptor | Candesartan | 2 h | Vauquelin and Van Liefde, 2006 |
| Olmesartan | 70 min | ||
| Neurokinin 1 receptor | aprepitant | 3.6 h | Hale et al., 1998 |