Figure 2.

The effect of vehicle (4% DMSO, 1% Tween 80 in physiological saline), 10 mg·kg⁻¹ or 20 mg·kg⁻¹ AM6545 administered 1 h prior to vehicle, WIN55212-2 (1 mg·kg⁻¹) or loperamide (1 mg·kg⁻¹) on colonic propulsion in mice. Bars represent the mean ± s.e.mean, n = 6–7. **P < 0.01 and ***P < 0.001 denote a significant difference between groups analysed using one-way anova followed by Bonferroni's multiple comparisons post hoc test.