Figure 4.
The effect of vehicle (4% DMSO, 1% Tween 80 in physiological saline) or AM6545 (5 or 10 mg·kg−1) on short-term food intake in rats (A). Bars represent the mean ± s.e.mean, n = 6–7. ***P < 0.001 denotes a significant difference to vehicle control analysed using one -way anova followed by Bonferroni's post hoc test. The effect of vehicle (4% DMSO, 1% Tween 80 in physiological saline) or AM6545 (10 mg·kg−1) on food intake (B) and weight change (C) in rats. Data points represent the mean ± s.e.mean, n = 4. *P < 0.05, **P < 0.01 and ***P < 0.001 denote a significant difference from vehicle control analysed using two-way mixed design anova with time as the repeated measure followed by Bonferroni's post hoc test.