Table 2.
AM6545 or AM4113 levels in the brain and plasma of rats or mice at specified time points after the i.p. administration of the antagonist
| Species | Time point (h) | Treatment (mg·kg−1) | Brain [antagonist] (ng·g−1) | Plasma [antagonist] (ng·mL−1) | Brain : plasma ratio |
|---|---|---|---|---|---|
| Rat | 1 | 10 AM6545 | 29.7 ± 9.8 | 178.1 ± 99.4 | 0.18 ± 0.11 |
| 10 AM4113 | 63.6 ± 6.2 | 49.3 ± 5.9 | 1.30 ± 0.18 | ||
| 3 | 10 AM6545 | 58.8 ± 4.8 | 267.9 ± 91.9 | 0.23 ± 0.06 | |
| 10 AM4113 | 123.4 ± 15.6 | 36.2 ± 8.5 | 4.73 ± 2.62 | ||
| 5 | 10 AM6545 | 41.9 ± 26.3 | 123.5 ± 114.0 | 0.41 ± 0.12 | |
| 10 AM4113 | 79.5 ± 27.3 | 22.7 ± 14.1 | 3.56 ± 0.61 | ||
| Mouse | 1 | 5 AM6545 | 20.7 ± 5.5 | 197.0 ± 0.1 | 0.13 ± 0.08 |
| 3 | 5 AM6545 | 39.4 ± 11.4 | 195.0 ± 0.2 | 0.10 ± 0.01 | |
| 17 | 5 AM6545 | 11.3 ± 1.4 | 153.4 ± 0.2 | 0.20 ± 0.06 |
Data represent the mean ± s.e.mean, n = 3–4.