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. 2010 Dec 15;137(24):4147–4158. doi: 10.1242/dev.052506

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Fig. 4. — Clonal Hpo pathway inactivation induces non cell-autonomous effects. (A-B′) Flipout clones overexpressing Yki (B-B′) induce an increase in Dl compared with control (A-A′). Nuclei are stained with DAPI (blue); GFP is green and Dl is in red. (C-E′) Cell-autonomous and non cell-autonomous increases in DNA replication rates (BrdU incorporation) upon induction of sav^shrp1 mutant GFP marked MARCM clones (C,C′) compared with neutral clones (E,E′). Higher magnification image of sav^shrp1 mutant clones (D,D′). GFP is green and BrdU is red. (F) BrdU labelling rates were quantified as the percentage of BrdU-positive cells per MARCM clone (cell autonomy) in sav^shrp1 mutants compared with neutral clones after 3D confocal imaging of the entire clone and subsequent 3D projection. ^*P>0.0001. (G) Number of BrdU-positive nuclei within all midgut cells, including clone and non-clone tissue (non-cell autonomy). ^*P>0.01. Scale bars: 20 μm.