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. 2010 Dec 15;137(24):4159–4169. doi: 10.1242/dev.056630

Fig. 3.

Fig. 3.

Significant effect of Cdx2 knockdown on mitochondrial activity. (A) Confocal images showing mitochondrial activity as assessed by JC-1 staining at the 8-cell, morula and blastocyst stages. siCdx2 treatment significantly reduced mitochondrial activity, as indicated by the accumulation of the red aggregated form of JC-1 in the mitochondria (appears yellow, as all mitochondria were stained with the green form of JC-1). (B) Measurement of ATP content in individual embryos, showing a significant increase in ATP from 0.17 pmol to 0.41 pmol in Cdx2-deficient blastocysts. Error bars indicate standard deviation.