Figure 5.

Survival curves for control and treated UM-HET3 (HET3) mice. Starting at 16–18 months of age, groups of about 60 females were given diets containing the following: aspirin, 21 ppm; nitroflurbiprofen (NFP), 200 ppm; 4-hydroxy phenyl N-tert-butyl nitrone (4-OH-PBN), 315 ppm; and nordihydroguaiaretic acid (NDGA), 2,500 ppm. Here, 1 ppm is 1 mg/kg of diet. None of these four treatments affected overall life span or maximum life span (proportion of mice in the longest-lived 40% survivorship). Note: The results from rapamycin-treated mice at The Jackson Laboratory are redrawn from Harrison et al. (11); they are provided here as an illustration of the potential for increased life span of HET3 mice when treatment is started late in life.