Table 1.

Effects of Diet Restriction on Life Spans and Weights of UM-HET3 (HET3) and CByB6F1/J Mice

						Weight (g), Mean ± SD
Stock	Sex	Diet	Life Span, Mean ± SD	n	Oldest 2 Mice (d)	90 d	240 d	480 d
HET3	F	Ad lib	836 ± 171	16	994; 1,032	24 ± 2	35 ± 7	41 ± 9
		DR	1,169 ± 195	16	1,382; 1,383	19 ± 2	22 ± 2	21 ± 2
	M	Ad lib	831 ± 237	14*	1,115; 1,320	34 ± 5	45 ± 6	47 ± 4
		DR	1,101 ± 256	16	1,412; 1,426	26 ± 2	29 ± 2	25 ± 2
CByB6F1	F	Ad lib	859 ± 205	16	1,164; 1,178	25 ± 3	—	—
		DR	1,283 ± 137	16	1,421; 1,653	17 ± 1	20 ± 1	—
	M	Ad lib	839 ± 227	16	1,108; 1,108	34 ± 2	48 ± 4	51 ± 6
		DR	1,154 ± 185	16	1,370; 1,370	20 ± 1	24 ± 2	28 ± 3

Notes: DR = diet restriction. HET3 mice are the first-generation four-way cross mice of CByB6F1/J females crossed with C3D2F1/J males. Results of statistical tests for life span are given in Figure 1.

^*Two mice were not included in the determination of mean life span because they were recorded as missing before they were 1 year old, presumably due to reasons not reflecting aging; the remaining censored mice (see Figure 1) were included in the mean life span calculation with the age at censoring as their life span.