Table 2.
Frequency Distribution of the Genotypes Defined by Combinations of Whether Carrying the Minor Allele of One of the Three SNPs of FOXO3A and Whether Carrying the Minor Allele of 1A-209, and the Estimates of the Odds Ratios of Survival Probability (RSij/00) from Middle Age to Ages 100+ Measuring the “Independent and Joint Effects” of the Genotypes
| Carrier or noncarrier of the minor allele of the SNPs of FOXO3A | Noncarrier of minor allele of 1A-209 (i = 0) | Carrier of minor allele of 1A-209 (i = 1) | ||||||
| Cent. % genotype | Contr % genotype | RSij/00 (95% CI) | p | Cent. % genotype | Contr % genotype | RSij/00 (95% CI) | p | |
| Women | ||||||||
| 3A-310, noncarrier (j = 0) | 27.8 | 26.6 | 1.00 | 20.2 | 34.0 | 0.57 (0.39–0.83) | 0.002 | |
| 3A-310, carrier (j = 1) | 29.9 | 21.7 | 1.32 (0.89–1.94) | 0.148 | 22.1 | 17.7 | 1.19(0.79–1.81) | 0.389 |
| 3A-292, noncarrier (j = 0) | 27.7 | 26.6 | 1.00 | 20.5 | 33.6 | 0.58 (0.40–0.85) | 0.004 | |
| 3A-292, carrier (j = 1) | 30.1 | 21.9 | 1.31 (0.89–1.93) | 0.148 | 21.7 | 17.9 | 1.16(0.76–1.76) | 0.462 |
| 3A-936, noncarrier (j = 0) | 28.8 | 28.2 | 1.00 | 21.6 | 34.6 | 0.61 (0.42–0.88) | 0.006 | |
| 3A-936, carrier (j = 1) | 28.9 | 19.9 | 1.41 (0.95–2.10) | 0.073 | 20.7 | 17.3 | 1.17(0.77–1.78) | 0.451 |
| Men | ||||||||
| 3A-310, noncarrier (j = 0) | 23.3 | 29.3 | 1.00 | 20.6 | 27.8 | 0.93 (0.55–1.55) | 0.755 | |
| 3A-310, carrier (j = 1) | 35.0 | 22.3 | 1.96 (1.23–3.15) | 0.003 | 21.1 | 20.6 | 1.28(0.76–2.16) | 0.322 |
| 3A-292, noncarrier (j = 0) | 23.8 | 29.6 | 1.00 | 19.9 | 27.8 | 0.89 (0.53–1.49) | 0.636 | |
| 3A-292, carrier (j = 1) | 34.8 | 22.0 | 1.96 (1.23–3.15) | 0.003 | 21.5 | 20.6 | 1.30(0.77–2.17) | 0.292 |
| 3A-936, noncarrier (j = 0) | 26.6 | 31.6 | 1.00 | 21.5 | 28.3 | 0.91 (0.55–1.49) | 0.686 | |
| 3A-936, carrier (j = 1) | 32.0 | 19.9 | 1.92 (1.20–3.06) | 0.004 | 19.9 | 20.2 | 1.17(0.70–1.96) | 0.522 |
Note: (1) The sample size is the same as that listed in Table 1. (2) The odds ratio 1.00 refers to the reference group with a genotype without carrying the minor allele of any of the two SNPs paired for the analysis; the values in italics in this table present the estimates of the “joint” effects of carrying the minor allele of SNP 1A-209 and carrying the minor allele of one of the three SNPs of FOXO3A; and the rest present the estimates of the “independent” effects of carrying the minor allele of one of the three SNPs of FOXO3A but not-carrying the minor allele of the SNP 1A-209, or carrying the minor allele of the SNP 1A-209 but not-carrying the minor allele of one of the three SNPs of FOXO3A. CI = confidence interval; SNP = single-nucleotide polymorphisms.