Table 3.
Frequency Distribution of the Genotypes Defined by Combinations of Whether Carrying the Minor Allele of One of the Three SNPs of FOXO3A and Whether Carrying the Minor Allele of 1A-213, and the Estimates of the Odds Ratios of Survival Probability (RSij/00) From Middle Age to Ages 100+ Measuring the “independent and joint effects” of the genotypes
| Carrier or noncarrier of the minor allele of the SNPs of FOXO3A | Noncarrier of minor allele of 1A-213 (i = 0) | Carrier of minor allele of 1A-213 (i = 1) | ||||||
| Cent. % genotype | Contr % genotype | RSij/00 (95% CI) | p | Cent. % genotype | Contr % genotype | RSij/00 (95% CI) | p | |
| Women | ||||||||
| 3A-310, noncarrier (j = 0) | 19.2 | 18.8 | 1.00 | 28.7 | 41.7 | 0.68 (0.45–1.00) | 0.043 | |
| 3A-310, carrier (j = 1) | 23.0 | 14.6 | 1.55 (0.97–2.48) | 0.052 | 29.1 | 24.9 | 1.15(0.76–1.75) | 0.489 |
| 3A-292, noncarrier (j = 0) | 19.0 | 18.8 | 1.00 | 29.1 | 41.3 | 0.70 (0.47–1.03) | 0.061 | |
| 3A-292, carrier (j = 1) | 23.2 | 14.8 | 1.55 (0.97–2.47) | 0.052 | 28.7 | 25.1 | 1.14(0.74–1.73) | 0.534 |
| 3A-936, noncarrier (j = 0) | 20.1 | 19 | 1.00 | 30.3 | 43.7 | 0.66 (0.45–0.97) | 0.029 | |
| 3A-936, carrier (j = 1) | 22.1 | 13.8 | 1.53 (0.95–2.47) | 0.066 | 27.5 | 23.5 | 1.12(0.73–1.71) | 0.595 |
| Men | ||||||||
| 3A-310, noncarrier (j = 0) | 13.9 | 17.5 | 1.00 | 30.0 | 39.5 | 0.96 (0.55–1.69) | 0.867 | |
| 3A-310, carrier (j = 1) | 27.2 | 14.7 | 2.34 (1.30–4.25) | 0.002 | 28.9 | 28.3 | 1.29(0.74–2.29) | 0.352 |
| 3A-292, noncarrier (j = 0) | 14.3 | 17.7 | 1.00 | 29.3 | 39.7 | 0.91 (0.53–1.59) | 0.712 | |
| 3A-292, carrier (j = 1) | 27.1 | 14.5 | 2.29 (1.28–4.14) | 0.003 | 29.3 | 28.1 | 1.28(0.74–2.26) | 0.357 |
| 3A-936, noncarrier (j = 0) | 17.2 | 19.3 | 1.00 | 30.9 | 40.6 | 0.86 (0.51–1.45) | 0.538 | |
| 3A-936, carrier (j = 1) | 24.3 | 12.8 | 2.14 (1.21–3.81) | 0.005 | 27.6 | 27.3 | 1.14(0.67–1.96) | 0.617 |