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. Author manuscript; available in PMC: 2011 Oct 28.
Published in final edited form as: Cancer Lett. 2010 May 5;296(2):233–240. doi: 10.1016/j.canlet.2010.04.014

Figure 4. Combinations of SNDX-275 and melphalan significantly enhance acetylation of histone H3, and exhibit super-induction of molecular markers-associated with DNA damage response.

Figure 4

RPMI8226 and MM1.S cells were cultured with RPMI1640 (0.5% FBS) in the absence or presence of SNDX-275 (0.5 µM), melphalan (10 µM) alone or combinations of SNDX-275 and melphalan for 24 hrs. Cells were collected and subjected to western blot analyses with specific antibodies directed against (acetylated) Ac-Histone H3, Histone H3, or β-actin (A) or γH2A.X, H2A.X, P-CHK1, CHK1, P-CHK2, CHK2, or β-actin (B).