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. Author manuscript; available in PMC: 2011 Oct 28.
Published in final edited form as: Cancer Lett. 2010 May 5;296(2):233–240. doi: 10.1016/j.canlet.2010.04.014

Figure 5. SNDX-275 enhances melphalan-induced mitotic catastrophe in MM cells.

Figure 5

MM1.S cells were cultured with RPMI1640 (0.5% FBS) in the absence or presence of SNDX-275 (0.5 µM), melphalan (10 µM) alone or combinations of SNDX-275 and melphalan for 24 hrs. Cells were harvested and subjected to cytospin onto cell slides. A, Slides were stained with HE, examined, and pictures were taken under a photomicroscope. B, Pathologist was blinded on each slide set regarding the treatment groups. Cells that showed atypical mitotic figures, multi-nucleation, atypical chromosome clusters, and apoptosis were counted against normal cells, and reported in percentage.