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. Author manuscript; available in PMC: 2011 Nov 25.

Published in final edited form as: J Med Chem. 2010 Oct 22;53(22):7958–7966. doi: 10.1021/jm100593s

Scheme 1a — ^a(a) 1,3-dibromo-5,5-dimethylhydantoin, CH₂Cl₂; (b) i. HNO₃, H₂SO₄; ii. H₂SO₄; (c) SnCl₂, HCl; (d) HCOOH; (e) PtO₂, Pd/C, NaOH; (f) p-TsOH, β-D-ribofuranose 1,2,3,5-tetraacetate; (g) NH₃, MeOH; (h) Ac₂O, pyridine; (i) Pd(PPh₃)₄, AlMe₃, THF; (j) NH₃, MeOH; (k) acetone, p-TsOH, 2,2-dimethoxypropane; (l) NaH, MeCN, MeI; (m) TFA, H₂O; (n) i. PCl₃, CH₂Cl₂; ii. TFA, H₂O; (o) TMSCl, pyridine, I₂, DMF, (NBu₄)₃HP₂O₇.