Table 1.
| Compound | HeLa IC50 (7 h, µM) |
HeLa IC50 (24 h, µM) |
HeLa IC50 (48 h, µM) |
PV IC50 (µM) |
DENV2 IC50 (µM) |
|---|---|---|---|---|---|
| 2 | 17.66 | 6.68 | 2.20 | 1.01b | 5.46 (replicon) |
| 3 | 1.44 | 0.819 | 0.400 | 0.030c | ND |
| 4 | >100 | >100 | >10 | >10 | >10 (replicon) |
| 5 | >100 | >100 | >100 | >10 | >10 (replicon) |
| 6 | >100 | 0.986a | 0.224 | 0.011d | 0.877 (replicon) 0.062 (plaque) 0.039 (PCR) |
| 7 | >100 | >100 | >100 | >10 | >10 (replicon) |
a
Viability of cells was 33% after treatment with 6 at 100 µM.
b
SEM (standard error of the mean) = 16%
c
SEM = 36%
d
SEM = 6%
ND: not determined