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Uroselectivity of α1-blockers in decerebrate dogs23
| Intravenous injection | Urethral pressure (ID50, μg/kg) | Blood pressure (ED20, μg/kg) | Uroselectivity (BP/UP) |
|---|---|---|---|
| Silodosin | 3.15 | 8.03 | 2.55 |
| Tamsulosin | 1.73 | 0.59 | 0.35 |
| Prazosin | 11.8 | 2.46 | 0.21 |
Abbreviations: ID50, dose required to inhibit increase in intraurethral pressure by 50%; ED20, dose required to reduce blood pressure by 20%; BP, blood pressure; UP, urethral pressure.
