Table 2.
Coordinates in the Talairach Space of Structural Magnetic Resonance Imaging Component-A of Significant Gray Matter Reduction in Patients Versus Control Subjects
| Regions | Brodmann Area | Volume (cc) |
Random Effects: Max Value (x, y, z) |
Prior Study | |
|---|---|---|---|---|---|
| R/L | R | L | |||
| Positive | |||||
| Anterior Cingulate | 25 | .6/.4 | 3.5 (0, 5, −8) | 3.2 (−3, 5, −10) | (5, 8–10) |
| Precuneus | 7, 19, 39 | 1.9/.0 | 3.5 (27, −65, 36) | NS | (8, 10) |
| Subgenual Cingulate | 25 | .6/.7 | 3.4 (3, 8, −13) | 3.2 (−3, 11, −11) | (9, 10) |
| Inferior Frontal Gyrus | 9, 11, 13, 44, 45, 47 | 5.9/5.3 | 3.2 (53, 13, 27) | 3.4 (−21, 20, −16) | (8–10) |
| Precentral Gyrus | 6, 9, 13, 43, 44 | 6.0/1.0 | 3.3 (59, −4, 31) | 2.7 (−53, 15, 8) | (8–10) |
| Superior Temporal Gyrus | 13, 22, 38 | 3.6/2.4 | 3.3 (45, 19, −24) | 3.3 (−53, 9, 0) | (8–10) |
| Middle Frontal Gyrus | 6, 8, 9, 11, 46 | 1.6/1.0 | 3.2 (45, 13, 30) (13, 30, 45) | 2.6 (−21, 25, −16) | (5, 8, 9) |
| Orbital Gyrus | 11, 47 | 1.1/.4 | 3.2 (12, 31, −24) | 2.7 (−12, 31, −24) | (9, 10) |
| Rectal Gyrus | 11 | 1.6/1.7 | 3.1 (9, 28, −24) | 2.8 (−3, 22, −19) | (8–10) |
| Cuneus | 18 | 1.3/.0 | 3.1 (9, −78, 18) | ns | (8, 10) |
| Insula | 13 | 2.8/.8 | 3.1 (42, 1, 11) | 2.3 (−53, −37, 21) | (5, 8–10) |
| Lingual Gyrus | 17, 18 | .4.4/.3 | 3.0 (0, −91, −8) | 2.7 (0, −90, −3) | |
| Postcentral Gyrus | 1, 3, 43 | .8/.1 | 3.0 (48, −14, 15) | 2.2 (−53, −18, 51) | (5, 8–10) |
| Thalamus | 2.9/3.1 | 2.9 (9, −8, 9) | 3.0 (−9, −11, 14) | (5, 8–10) | |
| Medial Frontal Gyrus | 11, 25 | .3/.8 | 2.7 (3, 11, −16) | 2.9 (−3, 20, −16) | (8–10) |
| Superior Frontal Gyrus | 11 | .4/.1 | 2.8 (24, 37, −22) | 2.2 (−9, 54, −23) | (10) |
| Superior Parietal Lobule | 7 | .6/.0 | 2.6 (27, −68, 45) | NS | |
| Transverse Temporal Gyrus | 41, 42 | .4/.0 | 2.6 (48, −17, 12) | NS | (9, 10) |
| Inferior Parietal Lobule | 40 | .0/.3 | ns | 2.6 (−53, −40, 24) | (8–10) |
| Middle Temporal Gyrus | 20, 38 | .3/.1 | 2.4 (33, 1, −40) | 2.2 (−33, 7, −38) | (8–10) |
| Uncus | 28 | .3/.1 | 2.2 (24, 7, −28) | 2.1 (−21, 4, −30) | (9, 10) |
| Parahippocampal Gyrus | .0/.1 | ns | 2.1 (−12, −4, −17) | (5, 8, 10) | |
| Caudate | .1/.0 | 2.1 (9, −2, 14) | NS | (8–10) | |
| Superior Occipital Gyrus | .1/.0 | 2.0 (33, −77, 26) | NS | (10) | |
| Negative | |||||
| Cingulate Gyrus | 31, 32 | 1.2/.5 | 3.1 (3, −45, 41) | 2.6 (−3, −45, 41) | |
| Superior Frontal Gyrus | 6 | .8/.3 | 3.1 (15, −14, 64) | 2.6 (−15, −14, 64) | (22) |
| Precuneus | 7, 31 | 2.6/.4 | 2.9 (3, −47, 44) | 2.3 (−3, −42, 44) | (22) |
| Middle Temporal Gyrus | 39 | .0/.4 | ns | 2.9 (−56, −69, 28) | (22) |
| Angular Gyrus | 39 | .0/.3 | ns | 2.9 (−53, −68, 31) | (22) |
| Middle Frontal Gyrus | 6 | 1.4/.3 | 2.9 (21, −9, 58) | 2.6 (−42, 2, 39) | (22) |
| Medial Frontal Gyrus | 6 | .4/.1 | 2.9 (12, −11, 64) | 2.2 (−12, −11, 64) | (22) |
| Precentral Gyrus | 6 | .6/.3 | 2.8 (12, −17, 64) | 2.4 (−12, −17, 64) | (22) |
| Cuneus | 18 | .4/.3 | 2.5 (6, −99, 5) | 2.2 (−15, −92, 21) | (22) |
Prior Meta/Voxel-Based Morphometry Studies Showing Similar Regions of Gray Matter Differences Are Listed in the Last Column of the Table.