Fig. 5.
Effect of delayed MSC/IFN-β/GFP treatment on 4 T1 breast tumor progression. Mice were injected with MSC/GFP or MSC/IFN-β/GFP (1 × 106 cells/mouse) 5 days after 4 T1 implantation. Significant inhibition of tumor growth was observed on day 13 after tumor cell injection in the MSC/IFN-β/GFP as compared with the control group, p = 0.025, (a).Tumors were observed to grow rapidly in the control group (bleft panel) while tumor size was reduced in MSC/IFN-β/GFP treated mice (bright panel). As determined by BLI, tumor size was size significantly larger in MSC/GFP treated mice (cleft panel), while that in MSC/IFN-β/GFP treated mice were significantly reduced (cright panel). Extensive Metastatic tumors (arrows) were observed in lungs (dleft upper panel) and liver (dleft lower panel) of control mice. In contrast, few metastatic nodules were seen in the lungs from MSC/IFN-β/GFP treated mice (dright upper panel) and no metastatic nodules were observed in the livers from MSC/IFN-β/GFP treated mice (dright lower panel)