Table 1.
Genes up-regulated in PM and FD according to their GO categories. Total number of genes up-regulated in each muscle is shown in brackets. Percentages on the left and right of each GO group are related to the number of genes up-regulated in PM and FD, respectively
| Genes up-regulated in PM (49) | Genes up-regulated in FD (31) |
|---|---|
| 39%—Metabolic—13% | |
| AK1—Adenylate kinase 1 | CA3—Carbonic anhydrase III, muscle specific |
| ALDOA—Aldolase A, fructose-biphosphate | FABP3—Fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) |
| ATP2A1—ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 | LDHB—Lactate dehydrogenase B |
| ATP6—ATP synthase F0 subunit 6 | SERINC2—Serine incorporator 2 |
| CKM—Creatine kinase, muscle | |
| CKMT2—Creatine kinase, mitochondrial 2 (sarcomeric) | |
| COX3—Cytochrome c oxidase subunit III | |
| CYTB—Cytochrome b | |
| ENO3—Enolase 3 (beta, muscle) | |
| FBP2—Fructose-1,6-bisphosphatase 2 | |
| GAPDH—Glyceraldehyde-3-phosphate dehydrogenase | |
| GPD1—Glycerol-3-phosphate dehydrogenase 1 (soluble) | |
| GPI—Glucose phosphate isomerase | |
| LDHA—Lactate dehydrogenase A | |
| PFKM—Phosphofructokinase, muscle | |
| PGAM2—Phosphoglycerate mutase 2 (muscle) | |
| PGM1—Phosphoglucomutase 1 | |
| PKM2—Pyruvate kinase, muscle | |
| PYGM—Phosphorylase, glycogen, muscle | |
| 31%—Muscle contraction and constituents—26% | |
| ACTN3—Actinin, alpha 3 | ACTB—Actin, beta |
| CALM1—Calmodulin 1 | KBTBD10—Kelch repeat and BTB (POZ) domain containing 10 |
| CASQ1—Calsequestrin 1 | MRCL3—Myosin regulatory light chain MRCL3 |
| LOC520988—Similar to myosin-binding protein C, fast-type (Fast MyBP-C) | MSN—Moesin |
| MYH1—Myosin, heavy chain 1, skeletal muscle, adult | MYL2—Myosin, light chain 2, regulatory, cardiac, slow |
| MYL1—Myosin, light chain 1, alkali; skeletal, fast | MYL6—Myosin, light chain 6, alkali, smooth muscle and non-muscle |
| MYL3—Myosin, light chain 3, alkali; ventricular, skeletal, slow | PPP1R14A—Protein phosphatase 1, regulatory (inhibitor) subunit 14A |
| MYLPF—Fast skeletal myosin light chain 2 | TNNT1—Troponin T type 1 (skeletal, slow) |
| MYOM2—Myomesin (M-protein) 2, 165kDa | |
| MYOZ1—Myozenin 1 | |
| TNNC2—Troponin C type 2 (fast) | |
| TNNI2—Troponin I type 2 (skeletal, fast) | |
| TNNT3—Troponin T type 3 (skeletal, fast) | |
| TPM1—Tropomyosin 1 (alpha) | |
| TTN—Titin | |
| 24%—Transcription, RNA processing, protein synthesis and modification—26% | |
| ARIH2—Ariadne homolog 2 (Drosophila) | CLU—Clusterin |
| ASB16—Ankyrin repeat and SOCS box-containing 16 | CREG1—Cellular repressor of E1A-stimulated genes 1 |
| ATF4—Activating transcription factor 4 (tax-responsive enhancer element B67) | CRYAB—Crystallin, alpha B |
| CTDSP2—CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 | EEF1A1—Eukaryotic translation elongation factor 1 alpha 1 |
| GMPR—Guanosine monophosphate reductase | EIF2AK1—Eukaryotic translation initiation factor 2-alpha kinase 1 |
| ITGB1BP3—Integrin beta 1 binding protein 3 | LOC512251—Similar to heat shock 27kDa protein family, member 7 |
| LOC493779—18S ribosomal RNA | RPLP0—Ribosomal protein, large, P0 |
| MLF1—Myeloid leukaemia factor 1 | UBA52—Ubiquitin A-52 residue ribosomal protein fusion product 1 |
| PPP1R8—Protein phosphatase 1, regulatory (inhibitor) subunit 8 | |
| PTMA—Prothymosin, alpha (gene sequence 28) | |
| RPS7—Ribosomal protein S7 | |
| rRNA—Ribosomal RNA | |
| 6%—Muscle development and regeneration—16% | |
| CWF19L1—CWF19-like 1, cell cycle control | CSRP3—Cysteine and glycine-rich protein 3 |
| PEBP4—Phosphatidylethanolamine-binding protein 4 | FHL1—Four and a half LIM domains 1 (FHL1), transcript variant 3 |
| PDLIM7—PDZ and LIM domain 7 (enigma) | INO80B—INO80 complex subunit B |
| MUSTN1—Muskuloskeletal, embryonic nuclear protein 1 | |
| TPT1—Tumour protein, translationally controlled 1 | |
| 0.0%—Extracellular matrix—19% | |
| COL1A1—Collagen type I, alpha 1 | |
| COL1A2—Collagen type I, alpha 2 | |
| COL3A1—Collagen type III, alpha 1 | |
| DCN—Decorin | |
| SPARC—Secreted protein, acidic, cysteine-rich (osteonectin) | |
| VIM—Vimentin | |