Figure 1.

Structural brain changes with age. Comparisons of fractional anisotropy (blue), gray matter volume (green), and white matter volume (yellow) between young (aged 23–40 years), middle-aged (aged 41–60 years), and older (aged 60–82 years) adults. (A) Comparisons between the young and middle-aged groups revealed widespread reductions in fractional anisotropy and reductions in GM density predominantly in frontal lobe. (B) Comparisons between middle and older aged adults revealed later reductions in white matter and gray matter volume. (C) Comparisons between young and older adults revealed widespread reductions in all measures. Adapted from Giorgio et al. (2010) with permission.