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. 2010 Aug 10;18(11):1917–1926. doi: 10.1038/mt.2010.167

Figure 5.

Figure 5

Injection of PEG-POD~GDNF results in partial functional rescue of light-damaged retina. In order to evaluate the functional rescue of PEG-POD~GDNF-treated retinas, electroretinograms (ERGs) were performed 7 days post-light exposure. (a) Averages of scotopic ERG recordings for all eyes in each treatment condition. The a-wave is boxed in gray and shown in more detail. (b) The amplitude of both the a- and b-waves were measured and compared between injection conditions. PEG-POD~GDNF-injected eyes showed a 39% increase in amplitude in the a-wave compared to PEG-POD~Lux (P < 0.05) and 32% compared to buffer injected eyes (P < 0.01). Though not significant, the mean b-wave amplitude was increased in PEG-POD~GDNF-injected eyes by 31% compared to PEG-POD~Lux and by 27% compared to buffer-injected eyes. PEG-POD~GDNF, n = 12; PEG-POD~Lux, n = 9; buffer, n = 11. Mean ± SEM. GDNF, glial cell line-derived neurotrophic factor; PEG, polyethylene glycol; POD, peptide for ocular delivery.