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. Author manuscript; available in PMC: 2010 Nov 23.
Published in final edited form as: Nat Genet. 2009 Dec 6;42(1):83–88. doi: 10.1038/ng.498

Fig. 3.

Fig. 3

Effects of Skp2 inactivation on E2F deregulation, aberrant proliferation and apoptosis, and p27 expression in pituitary ILs following Rb1 deletion. Various indicated mice at the ages of PND 10 (post-natal day 10) and 4 weeks are presented in panels a and b, respectively. E2F deregulation is examined by PCNA expression, proliferation by Ki67 expression, and apoptosis by TUNEL labeling. Quantification of Ki67 and TUNEL labeling in ILs was performed with three pituitaries of each indicated genotypes at the indicated ages. Rb1 genotypes indicate the outcome of Cre-loxP mediated deletion in IL. p values are by t test. Error bars are s.d. Scale bar, 200 μm.