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. 2010 Oct 26;103(10):1597–1605. doi: 10.1038/sj.bjc.6605924

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Copyright © 2010 Cancer Research UK

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Kinetics of spleen reconstitution after bone marrow transplantation (BMT) and immunomodulation. (A) Percent recovery of spleen cellularity at 4 weeks after allogeneic BMT (allo-BMT) (H2K^b → H2K^a), infusion of F1 splenocytes (spln.) and tumour-pulsed dendritic cells (DCs) normalised against naïve C57/BL (B6) donors (n=5–6 for each point). (B) Fractional distribution of CD4⁺ and CD8⁺ T cells in the spleens of allografted mice in the various experimental protocols. (C) Dynamics of splenic cellularity in allografted mice and with adoptive transfer of F1 splenocytes on days 0 and +7 as a function of time elapsing from transplantation.