Table 3. Grades I–II and grades III–IV toxicities (N=95).

Toxicitya	Grades I–II, n (%)	Grades III–IV, n (%)
Haematological toxicity	34 (35.8)	9 (9.5)
Diarrhea	26 (27.3)	8 (8.5)
Mucositis	24 (25.3)	5 (5.3)
Asthenia	18 (19.0)	2 (2.1)
Emesis	10 (10.6)	1 (1.1)
Haemorrhagesb	11 (11.6)	0 (0.0)
Pain	9 (9.7)	1 (1.1)
Nausea	9 (9.5)	0 (0.0)
Hypertensionc	9 (9.5)	0 (0.0)
Constipation	6 (6.4)	0 (0.0)
Proteinuria	3 (3.2)	1 (1.1)
Hepatic toxicity	1 (1.1)	2 (2.1)
Alopecia	3 (3.2)	0 (0.0)
Headache	2 (2.1)	0 (0.0)
Colic	1 (1.1)	1 (1.1)
Hiccups	2 (2.1)	0 (0.0)
Thrombophlebitis	1 (1.1)	0 (0.0)
Wound healing problems	1 (1.1)	0 (0.0)
Allergic reactions	1 (1.1)	0 (0.0)
Dyspnea	1 (1.1)	0 (0.0)
Edema	1 (1.1)	0 (0.0)
Oesophagitis	1 (1.1)	0 (0.0)
Feverc	1 (1.1)	0 (0.0)
Neuropathy	1 (1.1)	0 (0.0)

^aInfection was also reported in one patient, and lung thromboembolism and haemorrhoids in two patients, but the grade was not recorded.

^bTwo patients had this adverse event, but the grade was not recorded.

^cOne patient had this adverse event, but the grade was not recorded.