Table 2. Major grade 2–4 toxicities before and after dose reductions.

	Patients experiencing toxicity (%)
Type of toxicity	Grade	Before dose reduction	After dose reduction	P-value
Diarrhoea	2	6	26	NS
	3	81	35	0.005
	4	13	1	0.006
Abdominal pain	2	31	25	NS
	3	2	7	0.05
	4	0	0	NS
Fatigue	2	43	37	NS
	3	8	12	NS
	4	2	0	NS
Nausea/vomiting	2	50	44	NS
	3	12	10	NS
	4	1	0	NS
Afebrile neutropenia	2	12	7	NS
	3	7	6	NS
Cutaneous rash	2	50	66	NS
	3	20	15	NS

Abbreviation: NS=not significant.