Table 2. The relationship between clinico-pathological variables and survival in patients undergoing potentially curative resection for colorectal cancer; univariate survival analysis.
|
Cancer-specific survival
|
Overall survival
|
||||
|---|---|---|---|---|---|
| Variable | 320 (%) | Hazard ratio (95% CI) | P-value | Hazard ratio (95% CI) | P-value |
| Age | |||||
| ⩽64 | 111 (35) | ||||
| 65–74 | 102 (32) | ||||
| ⩾75 | 107 (33) | 1.66 (1.26, 2.18) | 0.001 | 1.80 (1.45, 2.23) | <0.001 |
| Sex | |||||
| Male | 170 (53) | ||||
| Female | 150 (47) | 1.30 (0.84, 2.01) | 0.25 | 1.18 (0.84, 1.66) | 0.34 |
| Deprivation | |||||
| 1–2 | 12 (4) | ||||
| 3–5 | 99 (31) | ||||
| 6–7 | 209 (65) | 1.11 (0.74, 1.65) | 0.46 | 0.98 (0.72, 1.32) | 0.77 |
| Smoking | |||||
| Never | 135 (42) | ||||
| Current/previous | 185 (58) | 1.62 (1.02, 2.55) | 0.04 | 1.67 (1.17, 2.39) | 0.004 |
| Presentation | |||||
| Elective | 307 (96) | ||||
| Emergency | 13 (4) | 3.93 (1.80, 8.56) | <0.001 | 3.00 (1.53, 5.94) | 0.001 |
| Tumour site | |||||
| Colon | 197 (62) | ||||
| Rectum | 123 (38) | 0.84 (0.53, 1.32) | 0.45 | 1.09 (0.77, 1.54) | 0.62 |
| Differentiation | |||||
| Well/ moderate | 286 (89) | ||||
| Poor | 34 (11) | 1.26 (0.63, 2.52) | 0.51 | 1.58 (0.96, 2.59) | 0.07 |
| Dukes stage | |||||
| Dukes A | 38 (12) | ||||
| Dukes B | 153 (48) | ||||
| Dukes C | 129 (40) | 2.21 (1.51, 3.21) | <0.001 | 1.60 (1.21, 2.10) | 0.004 |
| Adjuvant therapy | |||||
| No | 254 (79) | ||||
| Yes | 66 (21) | 1.00 (0.59, 1.69) | 0.99 | 0.90 (0.59, 1.37) | 0.61 |
| mGPS | |||||
| Low (0) | 194 (61) | ||||
| Intermediate (1) | 90 (28) | ||||
| High (2) | 36 (11) | 1.71 (1.29, 2.27) | <0.001 | 1.60 (1.28, 2.01) | <0.001 |
| POSSUM physiology score | |||||
| Group 1 (11–14) | 109 (34) | ||||
| Group 2 (15–20) | 134 (42) | ||||
| Group 3 (21–30) | 69 (21) | ||||
| Group 4 (>30) | 8 (3) | 1.73 (1.33, 2.25) | <0.001 | 1.59 (1.29, 1.96) | <0.001 |
Abbreviation: CI=confidence interval.