Table 2. Percentages of toxicity of the docetaxel, cisplatin, tegafur/uracil, and leucovorin regimen.
Patients (n=45)
|
Cycles (n=271)
|
|||||||
---|---|---|---|---|---|---|---|---|
Grade
|
Grade
|
Grade
|
Grade
|
|||||
Toxicity | 1 | 2 | 3 | 4 | 1 | 2 | 3 | 4 |
Haematological | ||||||||
Neutropenia | 4a | 11 | 33 | 18 | 11b | 13 | 17 | 6 |
Leukopenia | 7 | 31 | 24 | 9 | 17 | 16 | 10 | 1 |
Thrombocytopenia | 18 | 9 | 2 | 2 | 21 | 2 | 0.4 | 0.4 |
Febrile neutropeniac | 0 | 0 | 4 | 0 | 0 | 0 | 1 | 0 |
Anaemia | 2 | 58 | 22 | 0 | 4 | 27 | 5 | 0 |
Gastrointestinal | ||||||||
Nausea | 31 | 22 | 7 | 0 | 19 | 6 | 1 | 0 |
Vomiting | 22 | 29 | 4 | 0 | 12 | 7 | 1 | 0 |
Diarrhoea | 22 | 33 | 13 | 2 | 16 | 14 | 3 | 0 |
Stomatitis | 13 | 22 | 7 | 0 | 5 | 11 | 4 | 0 |
Anorexia | 24 | 24 | 4 | 0 | 18 | 6 | 8 | 0 |
Weight loss | 20 | 16 | 2 | 0 | 10 | 6 | 0.4 | 0 |
Neurosensory | 7 | 2 | 0 | 0 | 10 | 1 | 0 | 0 |
Others | ||||||||
Hand and foot syndrome | 4 | 4 | 0 | 0 | 3 | 5 | 0 | 0 |
Fever | 16 | 7 | 0 | 0 | 6 | 1 | 0 | 0 |
Infections | 11 | 16 | 20 | 0 | 5 | 5 | 7 | 0 |
Alopecia | 36 | 9 | 0 | 0 | 31 | 5 | 0 | 0 |
All numbers are percentages of the 45 patients.
All numbers are percentages of the 271 cycles given.
Febrile neutropenia was defined as fever of unknown origin without clinically or microbiologically documented infection with absolute neutrophil count <1.0 × 109/l and fever ⩾38.5°C, according to the National Cancer Institute Common Terminology Criteria for Adverse Events 3.0.