Table 1.
Profile of adverse events seen with VNS in short term and long term trials
| Adverse event | Sackeim, et al., 2001 n=60 10 weeks | Rush, et al., 2005 n=119 10 weeks | Rush, et al., 2005 n=209 12 months | Nahas, et al., 2005 n=59 24 months |
|---|---|---|---|---|
| Hoarseness | 55% | 68% | 54% | 27% |
| Cough | 17% | 29% | 6% | -- |
| Dyspnea | 15% | 23% | 16% | 8% |
| Neck pain | 17% | 21% | 13% | 13% |
| Pain | 13% | -- | 6% | -- |
| Headache | 22% | -- | 4% | -- |
| Dysphagia | 13% | 21% | 4% | -- |
| Vomiting | -- | 21% | -- | -- |
| Nausea | 7% | -- | 2% | -- |
| Dyspepsia | 10% | 10% | 16% | -- |
| Palpitations | 5% | 5% | -- | -- |
| Paresthesiae | 7% | 16% | 4% | -- |
| Laryngismus | -- | 11% | 5% | -- |
| Pharyngitis | 13% | --- | 5% | -- |