Figure 6.

Reaction comparison of the three infection-specific models of iAB-AMØ-1410-Mt-661 for latent, pulmonary, and meningeal tuberculosis. (A) We used macrophage gene expression data from three types of M. tb infections to build context-specific models of iAB-AMØ-1410-Mt-661 for latent (L), pulmonary (P), and meningeal (M) tuberculosis. The models had significant differences in reactions for the macrophage and surprisingly M. tb. (B) There were many reactions with disparate activity between the three infections. We determined the subsystems of the reactions with differential activity. (C) The total number of disparate reactions was calculated. The left-most panel shows the macrophage reactions shown to be active in each state as calculated from the expression profile. This data was then used with the GIMME algorithm to build three flux-balance models using iAB-AMØ-1410-Mt-661. The middle diagram shows the active M. tb reactions in each model. The right-most diagram shows the active macrophage reactions in each model.