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. Author manuscript; available in PMC: 2011 Nov 15.
Published in final edited form as: Chem Res Toxicol. 2010 Oct 22;23(11):1701–1713. doi: 10.1021/tx100179g

Figure 6.

Figure 6

Reconstructed ion chromatograms of the LC-ESI/MS/MSn traces of CT-DNA treated with HNE. A reconstructed ion chromatogram of the LC-ESI/MS/MS3 trace for HNE-dG and the reconstructed ion chromatogram of the LC-ESI/MS/MS4 trace for the 8-dG-HNE-dG cross-link. Both [2H11]-HNE-dG and [2H11]-8-dG-HNE-dG cross-link were added to CT DNA at a level of 1 adduct per 107 bases. Panel A depicts untreated CT DNA and Panel B depicts CT DNA treated with 2 mol of HNE per mol base in CT DNA.