Table 4.
Anthropometric data at baseline and after 48 weeks of metformin
| Parameter | Pre | Week 48 | P-value* |
|---|---|---|---|
| Weight (kg) | 98.1 (24.6) | 92.2 (25.5) | 0.40 |
| BMI (kg/m2) | 33.9 (6.8) | 31.8 (7.3) | 0.28 |
| Waist circumference (cm) | 111.0 (16.6) | 107.6 (16.5) | 0.47 |
| Hip circumference (cm) | 113.2 (13.6) | 110.2 (13.7) | 0.17 |
| Waist/hip ratio | 0.98 (0.06) | 0.98 (0.05) | 0.86 |
| Total body fat (%) | 34.3 (9) | 33.2 (7.5) | 0.53 |
| Fat mass (kg) | 32.1 (10.0) | 29.5 (9.7) | 0.22 |
| Lean mass (kg) | 59.4 (15.3) | 57.3 (16.1) | 0.61 |
| Liver fat by MRI† (%) | 14.9 (9.4) | 13.0 (8.4) | 0.50 |
| Liver volume by MRI† (cc) | 2213 (547) | 2156 (580) | 0.74 |
| Total fat by CT (cm2) | 453 (210) | 460 (223) | 0.66 |
| Visceral fat by CT (cm2) | 200 (76) | 170 (66) | 0.001 |
| Subcutaneous fat by CT (cm2) | 254 (161) | 290 (185) | 0.008 |
Values are given as mean (s.d.).
BMI, body mass index; MRI, magnetic resonance imaging; CT, computerized tomography.
*
P-value based on two-sided paired t-test.
†
n = 16 patients.