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. Author manuscript; available in PMC: 2010 Nov 23.
Published in final edited form as: Cell Death Differ. 2009 Apr 17;16(8):1167–1179. doi: 10.1038/cdd.2009.37

Figure 2. Dose dependent GSSG toxicity.

Figure 2

A, 500 attomole GSH or GSSG (0, 12.5, 25, 50, 250, and 500 attomoles) was microinjected into the cytoplasm of HT4 cells for 24h. B, GSSG (0, 1.25, 2.5, 5 and 25 attomoles) was injected into the cytoplasm of HT4 cells pre-treated with 50 μM BSO for 12h. Cellular GSSG/total glutathione (C) was increased, and absolute value of GSH (μmol/ mg protein) was decreased after 50 μM BSO treatment (D). attomoles injected [micromolar]i, n=3, Results are mean ± S.D. *, p < 0.05.