Table 6.
Top 10 Alzheimer Disease Genes ranked on Genotator score.
| Gene | Score | Literature Support | Reference |
|---|---|---|---|
| APOE | 513 | Effect of APOE genotype on amyloid plaque load and gray matter volume in Alzheimer disease. | [52] |
| PSEN1 | 45.4 | Early Onset Alzheimer's Disease with Spastic Paraparesis, Dysarthria and Seizures and N135 S Mutation in PSEN. | [53] |
| ACE | 28.4 | Amyloid-beta-Related Genes SORL1 and ACE are Genetically Associated With Risk for Late-onset Alzheimer Disease in the Chinese Population. | [54] |
| PRNP | 23.1 | Earlier onset of Alzheimer's disease: risk polymorphisms within PRNP, PRND, CYP46, and APOE genes. | [55] |
| BCHE | 22.7 | Dipeptidyl carboxypeptidase 1 (DCP1) and butyrylcholinesterase (BCHE) gene interactions with the apolipoprotein E epsilon4 allele as risk factors in Alzheimer's disease and in Parkinson's disease with coexisting Alzheimer pathology. | [56] |
| APOC1 | 20.8 | APOE and APOC1 promoter polymorphisms and the risk of Alzheimer disease in African American and Caribbean Hispanic individuals | [57] |
| IL1B | 19.9 | Assessment of Alzheimer's disease case-control associations using family-based methods. | [58] |
| IL1A | 19.5 | Pharmacogenomics in Alzheimer's disease. | [59] |
| MTHFR | 19.3 | Association of MTHFR gene polymorphism C677T with susceptibility to late-onset Alzheimer's disease. | [60] |
| BDNF | 17.5 | Association between BDNF Val66Met polymorphism and Alzheimer disease, dementia with Lewy bodies, and Pick disease. | [61] |
The table lists the title and reference of the research study supporting the gene-disease association together with the official gene symbol. A complete set of results is available online as Additional file 3.