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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: Inflamm Bowel Dis. 2010 Aug 18;17(3):711–719. doi: 10.1002/ibd.21437

Figure 7. TNBS-induced decreased apoptosis in smooth muscle cells is accentuated in IGF-I(+/−) mice.

Figure 7

Levels of apoptosis in muscle cells of vehicle treated IGF-I(+/−) mice were lower than in vehicle treated wildtype mice. Apoptosis was decreased further in wildtype and IGF-I(+/−) mice with TNBS treatment compared to vehicle treated mice. The decrease with TNBS treatment in IGF-I(+/−) mice was lower than in wildtype mice. Inset: Representative immunoblots of cleaved caspase-3(Asp-175), total caspase-3 and β-actin. Apoptosis was measured cleaved caspase-3(Asp-175)/total caspase-3 levels and results expressed as the relative levels after normalization to β-actin levels. Values represent the mean ± SE of 8 animals in each group. * denotes P < 0.05 vs vehicle treated wildtype mice, ** denotes P < 0.05 vs TNBS treated wildtype mice.