Table 1.
Clinical characteristics of gastric acid normosecretors and hypersecretors postcurative resection(1)
| Clinical Characteristic |
Number (percent)(8) |
||
|---|---|---|---|
| Normosecretors |
Hypersecretors |
||
| (n=19) |
Moderate (n=17) |
Extreme (n=14) |
|
| Age at surgery (yrs) | 51 ± 3 | 54 ± 2 | 49 ± 2 |
| Males | 12 (63%) | 11 (65%) | 11 (79%) |
| Age at ZES onset (yrs)(2) | 41 ± 2 | 44 ± 3 | 42 ± 3 |
| Age at ZES diagnosis (yrs) | 49 ± 3 | 49 ± 3 | 47 ± 2 |
| Duration of symptoms at surgery (yrs) | 10 ± 2 | 10 ± 2 | 6 ± 2 |
| Duration from diagnosis to surgery (yrs) | 2 ± 1 | 4 ± 1 | 2 ± 1 |
| Duration from ZES onset to postop highest BAO (yrs)(3) | 14 ± 2 | 14 ± 2 | 10 ± 2 |
| Duration from diagnosis to postop highest BAO (yrs) | 7 ± 1 | 8 ± 1 | 6 ± 1 |
| Duration from surgery to postop highest BAO (yrs) | 5 ± 1 | 4 ± 1 | 4 ± 1 |
| Disease-free follow-up from diagnosis (yrs)(4) | 11 ± 1 | 12 ± 1 | 10 ± 1 |
| Symptoms and signs at diagnosis (preoperatively)(5) | |||
| Diarrhea | 15 (79%) | 14 (82%) | 12(86%) |
| Heartburn | 9 (47%) | 9 (53%) | 7 (50%) |
| Bleeding | 4 (21%) | 4 (24%) | 6 (43%) |
| Ulcers(6) | 13 (68%) | 12 (71%) | 8 (57%) |
| Gastric acid-reducing surgery(7) | 2 (11%) | 4 (24%) | 3 (21%) |
Secretory status is based on highest basal acid output (BAO) measured postoperatively (with or without previous gastric surgery): normosecretors BAO <5 or <15; moderate 5–14.9 or 15–24.9; extreme hypersecretors ≥15 or ≥25 mEq/h, respectively.
ZES onset is the time of onset of continuous symptoms compatible with ZES [27].
Highest BAO is the highest basal acid output measured at anytime postoperatively, from beyond 1 year post-resection and prior to at least 2 years before the last disease-free visit.
This is the time interval from the diagnosis of ZES to the last disease-free visit at the NIH following curative resection.
Initial symptoms and signs present prior to the diagnosis of ZES.
Diagnosed at endoscopy or by upper gastrointestinal series.
Includes patients with parietal cell vagotomy (n=5), vagotomy and drainage procedure or with a partial gastrectomy (Billroth I - 2 patients, Billroth II - 2 patients) with or without vagotomy.
Number refers to the number of patients with the indicated clinical characteristic. The percent is the proportion of the total number of patients in the indicated secretory group with the indicated clinical characteristic.
Abbreviations: ZES - Zollinger-Ellison syndrome, BAO - basal acid output