Table 5.
Postoperative antisecretory drug requirements and control of gastric acid in normosecretors and hypersecretors postcurative resection(1)
| Number (percentage) |
|||
|---|---|---|---|
| Normosecretors |
Hypersecretors(1) |
||
| (N=19) |
Moderate (n=17) |
Extreme (n=14) |
|
| Postoperative acid secretion control | |||
| Control (mEq/hr)(2) | |||
| 6 mos postop | 2.5 ± 0.6 | 2.5 ± 0.5 | 3.1 ± 1.1 |
| 1 year postop | 2.1 ± 0.6 | 2.8 ± 0.5 | 3.2 ± 1.1 |
| 1 year postop | 2.1 ± 0.6 | 2.8 ± 0.4 | 3.1 ± 1.0 |
| No. with achlorhydria(3) | 3 (15%) | 1 (6%) | 0(0%) |
| No. with sustained hypochlorhydria (3) | 3 (15%) | 1 (6%) | 0(0%) |
| Postop antisecretory drug/dose | |||
| No. patients taking no drug/H2R antag ≥6mos(4) | 9 (47%) | 10(53%) | 5 (36%) |
| No. patients with drug dosage reduced postop (4) | 19(100%) | 17(100%) | 14(100%) |
| Median postoperative dosage of omeprazole in patients requiring PPI (mg/day) | 20 | 20 | 20 |
(1)
Secretory groups are as defined in Table 1 legend.
(2)
Acid secretion one hour prior to next dose of antisecretory drug for patients taking antisecretory drugs (n=40)
(3)
Definitions as outlined in [50] with drug induced achlorhydria requiring no acid detected at any follow-up on drug and sustained hypochlorhydria requiring acid secretion reduced to <0.2mEq/hr in >50% of follow-ups.
(4)
Antisecretory drug dosage was attempted to be reduced in all patients postoperatively as described in methods with the aim if possible to remove all antisecretory drug.