Table 2.

Randomized controlled trials

Principal author	Study design	Participants	Intervention
Hoeger20	Prospective randomized trial over 48 wk	38 obese women with PCOS, whose insulin failed to normalize after 4 mo on the diet	Metformin (n = 9) vs Lifestyle modification + placebo (n = 11) vs Metformin + lifestyle modification (n = 9) vs Placebo (n = 9)
Lemay17	Prospective randomized cross-over trial over 12 mo following 4 mo diet	28 overweight or obese women with PCOS (23 completers)	Group A: rosiglitazone + diet for 6 mo (n = 15) Group B: oral contraceptive (EE/CPA) + diet for 6 mo (n = 13) At 6 mo, groups A and B commenced rosiglitazone + EE/CPA for further 6 mo
Gambineri18	Prospective randomized controlled trial over 12 mo	80 overweight or obese women with PCOS (76 completers)	Diet + placebo (n = 19) vs Diet + metformin (n = 20) vs Diet + flutamide (n = 17) vs Diet + metformin + flutamide (n = 20)

Note: This table provides intervention details for the three randomized controlled trials that were included in this review.

Abbreviation: PCOS, polycystic ovary syndrome.