Table 1.
Receptor usage of CCL3–CCL4- and CCL3L–CCL4L-derived proteins.
| CCR1 | CCR2b | CCR3 | CCR5 | Anti-HIV activity | |
|---|---|---|---|---|---|
| CCL3/CCL3L1 | |||||
| CCL3(1–70) | Yes/+++ | No | No | Yes/++ | Yes/++ |
| CCL3(5–70) | Yes/++++ | No | No | Yes/+++ | Yes/++ |
| CCL3L1(1–70) | Yes/++ | No | Yes/+++ | Yes/++++ | Yes/++++ |
| CCL3L1(3–70) | Yes/++++ | No | Yes/+ | Yes/+++++ | Yes/++++ |
| CCL3L1(5–70) | Yes/+++ | No | No | Yes/+++ | Yes/++ |
| CCL3L2 | ? | ? | ? | ? | ? |
| CCL4/CCL4L1/CCL4L2 | |||||
| CCL4 | Yes/+ | No | Yes/+ | Yes/+++ | Yes/+++ |
| CCL4(3–69) | Yes/+++ | Yes/+++ | No | Yes/+++ | Yes/+++ |
| CCL4L1 | Yes/+ | No | Yes/+ | Yes/+++ | Yes/+++ |
| CCL4L2 | ? | ? | ? | ? | ? |
HIV: human immunodeficiency virus.