Fig. 6.

Ex vivo effect of the four p38 inhibitor compounds on interleukin (IL)-1β, IL-6 and tumour necrosis factor (TNF)-α production by inflammatory bowel disease (IBD) biopsies. Cytokine levels (pg/ml) were measured by enzyme-linked immunosorbent assay in the supernatants of mucosal biopsies collected from inflamed areas of seven Crohn's disease patients and seven ulcerative colitis patients, and cultured in the presence or absence of p38α inhibitor compounds 1, 2, 3 or SB203580, all at a final concentration of 10 µM. Results are mean (standard deviation) (*P < 0·005, **P < 0·01 and §P < 0·05 versus medium only).