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p38 inhibitor profile of the three novel p38 inhibitor compounds used. All values are pIC50s in non-cellular assay systems.
| p38 inhibitor | p38α | p38β | p38γ/p38δ | Broader kinase selectivity |
|---|---|---|---|---|
| 1 | 7·6 | 7·4 | < 5 | No issues |
| 2 | 7·2 | 6·9 | < 5 | No issues |
| 3 | 7·2 | 6·9 | < 5 | No issues |
| SB203580 | 7·1 | 7·1 | < 5 | Some non-selectivity issues (JNK) |
JNK: Jun N-terminal kinase.
