Table A1.
Summary of neuropsychological performance by cognitive domain in published studies comparing HCV+ adults to HCV− controls without liver disease (LD)
| Study groups | Language/ Fluency |
Verbal Memory |
Visuospatial Memory |
Auditory Attention |
Speeded Visual Processing |
Motor Speed | Visuomotor Construction |
Reasoning/ Mental Flexibility |
Any cognitive problems |
|
|---|---|---|---|---|---|---|---|---|---|---|
|
Forton et al. (2002) (England) |
27 HCV+/mild LD 16 HCV−/HCV cleared |
— | ? | ? | — | Y | — | — | — | Y |
|
Cordoba et al. (2003) (Spain) |
40 HCV+/mild LD 40 HCV+/compensated cirrhosis 40 HCV+/decompensated cirrhosis 40 HCV− |
N | N | — | N | N | N | — | — | N |
|
Martin et al. (2004) (United States) |
20 HCV+/HIV−/SUD+ 28 HCV+/HIV+/SUD+ 39 HCV−/HIV+/SUD+ 69 HCV−/HIV−/SUD+ |
— | — | — | — | Y | — | — | — | Y |
|
von Giesen et al. (2004) (Germany) |
44 HIV−/HCV+ 43 HIV+/HCV− 43 HIV+/HCV+ 98 HIV−/HCV− |
— | — | — | — | — | Y | — | — | Y |
|
Weissenborn et al. (2004) (Germany) |
15 HCV+/mild fatigue 15 HCV+/moderate fatigue 15 HCV− |
— | Y | Y? | N | Y | — | N | Y | Y |
|
McAndrews et al. (2005) (Canada) |
37 HCV+ 46 HCV− |
— | Y | N | N | N | — | — | — | Y |
|
Cherner et al. (2005)/ Letendre et al. (2005) (United States) |
2 HCV+/HIV−/Meth− 33 HCV+/HIV−/Meth+ 8 HCV+/HIV+/Meth− 40 HCV+/HIV+/Meth+ 83 HCV−/HIV−/Meth+ 105 HCV−/HIV+/Meth− 69 HCV−/HIV+/Meth+ 90 HCV−/HIV−/Meth− |
N | Y | Y | N | N | Y | — | Y | Y |
|
Karaivazoglou et al. (2007) (Greece) |
32 HCV+ 20 HCV− 29 HBV+ |
N | Y | — | — | N | — | — | — | Y |
| Huckans et al. (2008) (United States) |
24 HCV+/SUD− 39 HCV+/SUD+ 56 HCV−/SUD− |
N | Y | N | Y | Y | N | N | Y | Y |
Note. Y = Compared with HCV− controls, HCV+ patients were found to perform worse on cognitive tests. N = HCV+ patients did not perform worse than HCV− controls on cognitive tests. — = Cognitive domain was not measured directly. ? = It is unclear from the published manuscript whether tests within this cognitive domain were used. LD = liver disease; Meth = recent methamphetamine abuse; SUD = history of substance use disorder.