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. Author manuscript; available in PMC: 2011 Jan 5.
Published in final edited form as: Genes Brain Behav. 2010 Jan 5;9(3):335–347. doi: 10.1111/j.1601-183X.2010.00564.x

Figure 1.

Figure 1

Haplotypes of the rhTPH2 5′-FR and their effects on reporter gene expression. (a) Trace chromatograms of −1454A>G and −1325In>Del(TA) polymorphisms; (b) Illustration of 5′-FR polymorphisms in rhTPH2 and hTPH2; (c) rhTPH2 5′-FR haplotypes and their frequencies in the cohort of 32 monkeys; (d) Luciferase activity driven by rhTPH2 5′-FR haplotypes in RN46A and HEK-293 cells. Except for the deletion construct (M0), all haplotypes occur naturally for the loci between −1605 and −1325. M3 has the dominant prevalence in the population and is thus regarded as the wild-type haplotype. M4′/M5′ differs from M4/M5 only at the −1454 locus, with the former followed by a prime (') indicating a “G” substitution at −1454. Data are shown as Mean ± SEM.