Table 3.
Odds of breast cancer (OR (95% CI))1 associated with ever (yes/no) consuming alcohol by tertiles of folate and vitamin B12 intake2
| Tertile 1 | Tertile 2 | Tertile 3 | P for interaction3 | |
|---|---|---|---|---|
| Folate | ||||
|
| ||||
| Mean±SD, μg/d2 | 197 ±47 | 317 ±36 | 532 ±145 | |
| Cases, n (%) | 231 (23) | 354 (35) | 415 (42) | |
| Controls, n (%) | 357 (33) | 356 (33) | 361 (34) | |
| Model 1 | 2.19 (1.54–3.15) | 2.42 (1.72–3.40) | 3.14 (2.26–4.37) | 0.01 |
| Model 2 | 1.99 (1.26–3.16) | 1.70 (1.10–2.63) | 1.12 (0.69–1.83) | 0.04 |
|
| ||||
| Vitamin B12 | ||||
|
| ||||
| Mean±SD, μg/d2 | 1.6 ±0.5 | 3.2 ±0.4 | 5.7 ±1.6 | |
| Cases, n (%) | 259 (26) | 361 (36) | 380 (38) | |
| Controls, n (%) | 357 (33) | 357 (33) | 360 (34) | |
| Model 1 | 2.00 (1.41–2.85) | 2.34 (1.68–3.26) | 2.53 (1.82–3.51) | 0.14 |
| Model 2 | 1.56 (1.01–2.43) | 1.52 (1.02–2.29) | 1.20 (0.78–1.86) | 0.47 |
Estimated from conditional logistic regression models using data from 1000 cases and 1074 controls (58.5% and 55.7% postmenopausal women, respectively: Model 1 Matching factors only (age, region, and health care institution) Model 2: Model 1+ BMI, family history of breast cancer, age at first pregnancy, number of births, lactation, energy intake, physical activity, education, age at menarche, menopausal status, OC (ever/never),smoking (ever/never), fibrocystic disease, hormone therapy
Folate and B12 intake were assessed by Food Frequency Questionnaire; Alcohol use assessed by Health Questionnaire.
P for interaction tested whether the association between alcohol consumption and breast cancer was modified by nutrient intake comparing nested models using the likelihood ratio test.