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. 2010 Sep 16;8(3):225–235. doi: 10.1016/j.chom.2010.08.002

Figure 2.

Figure 2

Regulation of MKP1, c-jun, c-Fos, and Cytokine Activation

(A) Levels of MKP1 phosphorylation 2 hr after C. albicans infection (MOI = 10) in TR146 cells after inhibition of different pathways.

(B) Level of inhibition of c-Jun (30 min) and c-Fos (3 hr) DNA binding activity after pretreatment for 4 hr with signaling pathway inhibitors.

(C and D) Effect of MKP1 and c-Fos knockdown, respectively, on cytokine production (MOI of 0.01).

Data are expressed as percentage of vehicle control levels (B–D) and are representative of three independent experiments (A) or are the mean of four independent experiments ± SEM (B–D). ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001. See also Figure S2.