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. 2010 Sep 16;8(3):225–235. doi: 10.1016/j.chom.2010.08.002

Figure 6.

Figure 6

Activation of the Biphasic MAPK Response May Be Required for Colonization in a Murine Model

(A and B) (A) Immunoblot analysis of MKP1 phosphorylation and (B) changes in transcription factor binding activity after infection with C. albicans SC5314 (noncolonizing) and 529L (colonizing).

(C) Morphology of C. albicans strains on epithelial cells after 30 min, 2 hr, and 24 hr.

(D) Secretion of cytokines after infection with C. albicans 529L and SC5314 for 24 hr.

An MOI of 10 was used for (A) and (B) and an MOI of 0.01 for (D) and (E). Data are (A and C) representative of three independent experiments or (B, D, and E) mean of three independent experiments ± SEM.