Table 2.
Serological data of patients with ocular adnexal MZBL with or without IgG4-positive plasma cells, and patients with ocular adnexal IgG4-related lymphoplasmacytic disorder
| Serological data (normal range) | IgG4-related group, n=10 | IgG4-unrelated group, n=61 | IgG4-related inflammatory group, n=10 | p Value* | p Value† |
| IgA (110–410 mg/dl) | 214 (109) | 228 (103) | 229 (149) | 0.6 | 0.7 |
| IgM (33–190 mg/dl) | 102 (58) | 157 (93) | 78 (58) | 0.02 | 0.09 |
| Total IgG (870–1700 mg/dl) | 2432 (1944) | 1287 (406) | 2732 (1749) | 0.003 | 1.0 |
| IgG1 (320–748 mg/dl) | 858 (193) | 655 (190) | 1047 (418) | 0.009 | 0.4 |
| IgG2 (208–754 mg/dl) | 607 (232) | 494 (172) | 836 (465) | 0.2 | 0.4 |
| IgG3 (7–88 mg/dl) | 86 (72) | 44 (35) | 66 (47) | 0.2 | 0.9 |
| IgG4 (5–105 mg/dl) | 415 (295) | 48 (46) | 901 (890) | <0.0001 | 0.2 |
| IgE (<170 IU/ml) | 1581 (1717) | 293 (509) | 1020 (1159) | <0.0001 | 0.2 |
| sIL-2R (135–483 U/ml) | 943 (525) | 465 (392) | 941 (579) | 0.0007 | 0.9 |
Values are mean (standard deviation).
IgG4-related group: patients having ocular adnexal MZBL with IgG4-positive plasma cells; IgG4-related inflammatory group: patients with ocular adnexal IgG4-related lymphoplasmacytic infiltrative disorder; IgG4-unrelated group: patients having ocular adnexal MZBL without IgG4-positive plasma cells.
*
IgG4-related group versus IgG4-unrelated group.
†
IgG4-related group versus IgG4-related inflammatory group.
MZBL, marginal zone B cell lymphoma; sIL-2R, soluble interleukin-2 receptor.