. Author manuscript; available in PMC: 2010 Nov 24.

Published in final edited form as: Sci Signal. 2010 Mar 9;3(112):re3. doi: 10.1126/scisignal.3112re3

Table 1.

Summary of the mouse Cnc knockout phenotypes.

Genotype	Phenotype	Reference
nrf1^−/−	Mid- to late embryonic lethal; defective erythropoiesis; oxidative stress	(129)
nrf2^−/−	Viable and fertile; age-related lupus-like syndrome (♀) and neurodegeneration (♀ and ♂); sensitivity to oxidative and ER stress	(130–134)
nrf1^−/−, nrf2^−/−	Enhancement of nrf1^−/− phenotypes: early embryonic lethal; increased oxidative stress	(136)
p45^−/−	Viable; mild anemia; thrombocytopenia (lack of platelets); death from hemorrhage	(20, 137)
p45^−/−, nrf2^−/−	No synthetic lethality; mild enhancement of p45^−/− phenotype (thrombocytopenia)	(138–140)
nrf3^−/−	No obvious phenotype	(22)
nrf3^−/−, nrf2^−/−	Viable and fertile	(22)
nrf3^−/−, p45^−/−	No synthetic lethality	(22)
nrf3^−/−, nrf2^−/−, p45^−/−	No synthetic lethality	(22)