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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Curr Opin Genet Dev. 2010 May 11;20(4):391–399. doi: 10.1016/j.gde.2010.04.008

Figure 3. The differential expression of members of the Gli/Ci family of transcription factors controls the response of progenitors to Shh in the ventral telencephalon at distinct embryonic ages.

Figure 3

(top panel) The distribution of Gli protein expression within the telencephalon at E9.5 [72] and (middle and bottom panels) E12.5 in patterns dictates the differential responses of progenitors to Shh. At E12.5, the targets of Shh-signaling Nkx6-2 (blue) and Gli1 (green) can be observed only in the Gli2-expressing domains (purple) that are closest to the ventral sources of Shh (red) along the rostro-caudal axis of the telencephalon. Gli3 (brown) is expressed in a dorsal-to-ventral gradient in the entire telencephalon with a characteristic low level of expression in the MGE (that is apparently insufficient to provide enough Gli-activator function to allow for expression of Nkx6-2 or Gli1).