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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Curr Opin Genet Dev. 2010 May 11;20(4):391–399. doi: 10.1016/j.gde.2010.04.008

Figure 4. Key genetic interactions involving Shh signaling that pattern and determine the fate of ventral telencephalic progenitors during C1 and C2 temporal competence windows.

Figure 4

During C1, Shh is indirectly required to establish the ventral expression of Nkx2-1 in the MGE anlage through a derepression of FGF signaling. At later stages, gene expression reveals that mostly positive Shh-signaling mediated through Gli proteins is associated with LGE/CGE development. It is at present unclear whether FGF-signaling plays a role during C2 inductive events.