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. Author manuscript; available in PMC: 2010 Nov 24.
Published in final edited form as: Dev Biol. 2009 Jan 15;325(2):363–373. doi: 10.1016/j.ydbio.2008.10.030

Fig. 6.

Fig. 6

Genetic interactions between stbm and lama1. All panels show dorsal views of the hindbrain with anterior to the left. Tg(isl1:gfp) embryos were fixed at 48 hpf, and processed for immunohistochemistry with zn5 antibody (red) to label dorsal commissural neurons and axons at rhombomere boundaries (A–F), and anti-GFP antibody (green) to label FBMNs (A–H; arrowheads). (A) FBMNs migrate normally in a control embryo. (B, C) Partial loss of FBMN migration in embryos injected with suboptimal dose of lama1 MO (B) or stbm MO (C). (D) Complete loss of FBMN migration in an embryo injected with suboptimal doses of lama1 and stbm MOs. (E) Partial loss of FBMN migration in a trilobitetc240a (tri) heterozygous (stbm+/−) embryo. (F) Complete loss of FBMN migration in a trilobite heterozygote injected with suboptimal dose of lama1 MO. (G) Greatly reduced FBMN migration in a bashfulb765 homozygous (lama1−/−) embryo. (H) Complete loss of FBMN migration in a trilobite; bashful double heterozygote. Scale bar in H (75 μm for A–H).