Table 2.
Lesion Depth and Behavioral/Electrophysiological Deficit Sensitivity
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Functional test | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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BMS subscore |
Footprint analysis |
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| Lesion depth | BMS | BMS subscore | Plantar stepping | Coordination | Paw position | Trunk stability | Tail position | Stride length | BOS | RI | Stance length | Toe drag | Beam walk | Toe spread | Hargreave's | tcMMEP |
| 0.5 mm | 7.4 | 6.8 | 0.0 | 5.3 | 12.0 | 5.3 | 5.3 | 0.6 | 6.9 | 1.1 | 5.3 | 6.4 | 21.4 | 9.1 | 1.2 | 5.9 |
| 0.8 mm | 8.9 | 8.1 | 0.0 | 11.9 | 10.5 | 9.3 | 5.2 | 3.8 | 3.7 | 1.7 | 1.7 | 6.5 | 23.0 | 3.0 | 2.6 | 0.1 |
| 1.1 mm | 5.8 | 8.5 | 1.8 | 6.2 | 9.8 | 8.0 | 12.5 | 5.1 | 3.8 | 0.8 | 1.6 | 5.5 | 13.5 | 4.8 | 2.8 | 9.7 |
| 1.4 mm | 28.0 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | 23.6 | 10.0 | 38.4 |
| 1.6 mm | 46.0 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | 54.0 | n/a | n/a |
Lesion depth and behavioral/electrophysiological deficit sensitivity: This table shows the deficit sensitivity measure (DSM). The formula is as follows: DSM = ((D*(S/T))/T))*100, where D is the magnitude of the deficit for each test, S represents the normal score for each test, and T represents the total scores of all the tests that each injury group was able to perform. For the 0.5-, 0.8-, and 1.1-mm groups, their total was based on 16 separate scores, while the 1.4-mm group's total was only based on 4, and the 1.6-mm group's total was only 2. Only one animal in the 1.4-mm group received a subscore at 42 dpi, thus no statistics were able to be run (n/a). Additionally, the 1.4- and 1.6-mm injured mice were not able to step consistently enough to perform the footprint test or the beam walk (n/a). The values in bold represent deficits that were significantly different from normal.